全以祖：类风湿性关节炎“病于全身，源于免疫”-国泰综合医院

类风湿性关节炎“病于全身，源于免疫”以慢性、对称性、多发性关节炎和关节外病变为主要临床表现，属于自身免疫炎性疾病，多数患者在接受系统性的诊疗后，都能有一定的疗效，我们的治疗目的在于调节免疫，控制关节及其他组织的炎症，缓解发病期的症状、防止关节畸形以及修复受损的关节以恢复其功能，保证患者的生活治疗不受较大的影响。类风湿可控，尽早治疗并遵循医嘱，让我们一起共抗风湿，早日回归正常生活。

全以祖：国泰综合医院内科部 风湿免疫科专任主治医师、国泰综合医院医学研究部 副主任、国泰综合医院临床医学研究中心主持人、辅仁大学医学系专任助理教授、台湾大学附设医院内科部 风湿免疫科兼任主治医师

。

全以祖医生，博士，毕业于国立台湾大学临床医学研究所，2007年2014年，先后担任台湾大学附设医院内科部住院医师、台湾大学附设医院内科部风湿免疫科总医师暨研究员、台湾大学附设医院新竹分院内科部 风湿免疫科主治医师。

特殊荣誉与得奖纪录:

2015年至2019年先后获得：财团法人沈水德翁文教基金会优秀论文奖、中华民国免疫学会最佳口头报告奖、第34届生物医学联合学术年会最佳口头报告奖、财团法人沈水德翁文教基金会优秀论文奖、2019亚洲克隆氏症及大肠炎学会研究奖助金。

主持计划：

著作:

1. Chyuan IT, Tsai HF, Wu CS,Hsu PN. TRAIL suppresses gut inflammation and inhibits colitogenic Tcell activation in experimental colitis via an apoptosis-independentpathway. Mucosal Immunol. 2019;12(4):980-989 (IF: 7.352)

2. Liao HJ, Tsai HF, Wu CS,Chyuan IT, Hsu PN. TRAIL inhibits RANK signaling and suppressesosteoclast activation via inhibiting lipid raft assembly and TRAF6recruitment. Cell Death Dis. 2019;10(2):77. (IF: 5.638)

3. Chyuan IT, Chen JY. Role ofInterleukin-(IL-)17 in the pathogenesis and targeted therapies inspondyloarthropathies. Mediators Inflamm. 2018;2018:2403935. (IF:3.549)

4. Chyuan IT, Tsai HF, Wu CS,Sung CC, Hsu PN. TRAIL-mediated suppression of T cell receptorsignaling inhibits T cell activation and inflammation inexperimental autoimmune encephalomyelitis. Front Immunol. 2018;9:15.(IF: 6.429)

5. Chyuan IT, Hsu PN. Tumornecrosis factor: The key to hepatitis B viral clearance. Cell MolImmunol. 2018;15(8):731-733. (IF: 7.551)

6. Yang NY, Wang CY, Chyuan IT,Wu KJ, Tu YK, Chang CW, Hsu PN, Kuo MY, Chen YW. Significantassociation of rheumatoid arthritis-related inflammatory markers withnon-surgical periodontal therapy. J Formos Med Assoc.2018;117(11):1003-1010. (IF: 2.452)

7. Chyuan IT, Tsai HF, Liao HJ,Wu CS, Hsu PN. An apoptosis-independent role of TRAIL in suppressingjoint inflammation and inhibiting T cell activation in inflammatoryarthritis. Cell Mol Immunol. 2018;15(9):846-857. (IF: 7.551)

8. Tsai HF, Wu CS, Chen YL,Liao HJ, Chyuan IT, Hsu PN. Galectin-3 suppresses mucosalinflammation and reduces disease severity in experimental colitis. JMol Med (Berl). 2016;94(5):545-56 (IF: 4.938)

9. Wang CY, Chyuan IT, Wang YL,Kuo MY, Chang CW, Wu KJ, Hsu PN, Nagasawa T, Wara-Aswapati N, ChenYW. β2-glycoprotein I-dependent anti-CL antibodies associatedwith periodonitis in SLE patients. J Periodontol.2015;86(8):995-1004. (IF: 3.392)

10. Chyuan IT, Tsai HF, TzengHT, Sung CC, Wu CS, Chen PJ, Hsu PN. Tumor necrosis factor-alphablockage therapy impairs hepatitis B viral clearance and enhances Tcell exhaustion in a mouse model. Cell Mol Immunol.2015;12(3):317-25. (IF: 7.551)

11. Liao HJ*, Chyuan IT*, WuCS, Lin SW, Chen KH, Tsai HF, Hsu PN. Increased neutrophilinfiltration, IL-1 production and a SAPHO syndrome-like phenotype inPSTPIP2-deficient mice. Rheumatology. 2015;54(7):1317-26 (IF: 5.245)*: co-first author

12. Chyuan IT, Tsai TH, ChangTH, Wu CS. Ustekinumab treatment in a patient with psoriasis andsystemic lupus erythematosus. Lupus. 2015;24(6):650-1. (IF: 2.969)

13. Tzeng HT, Tsai HF, ChyuanIT, Liao HJ, Chen CJ, Chen PJ, Hsu PN. Tumor necrosis factor-alphainduced by hepatitis B virus core mediating the immune response forhepatitis B viral clearance in mice model. PLoS One.2014;9(7):e103008. (IF: 2.766)

14. Wu CS, Hu CY, Tsai HF,Chyuan IT, Chan CJ, Chang SK, Hsu PN. Elevated serum level of growtharrest-specific protein 6 (Gas6) in systemic lupus erythematosuspatients is associated with nephritis and cutaneous vasculitis.Rheumatol Int. 2014;34(5):625-9. (IF: 1.952)

会议与座谈会:

1. Chyuan IT, Tsai HF, Hsu PN.An apoptosis-independent role of TRAIL mediates suppression of T cellactivation and autoimmune inflammation in experimental autoimmuneencephalomyelitis [Poster]. The Federation of Immunological Societiesof Asia-Oceania Congress (FIMSA), Thailand, 2018

2. Chyuan IT, Tsai HF, Hsu PN.TRAIL suppresses joint inflammation and osteoclastogenesis throughinhibiting activated T cell responses in inflammatory arthritis[Oral]. Cytokine Congress, Japan, 2017

3. Chyuan IT, Tsai HF, Hsu PN.An apoptosis-independent role of TRAIL in suppressing jointinflammation and inhibiting T cell activation in inflammatoryarthritis [Oral]. The 16th TNF Superfamily Meeting. Singapore, 2017

4. Chyuan IT, Tsai HF, Hsu PN.Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)suppresses joint inflammation and bone erosion by inhibiting T cellactivation in experimental arthritis [Oral]. The 16th InternationalCongress of Immunology. Australia, 2016

5. Chyuan IT, Tsai HF, Hsu PN.TRAIL modulates experimental autoimmune encephalomyelitis (EAE) bydirectly inhibiting myelin-specific T cells activation via TRAILreceptor signaling [Oral]. The Congress of the Chinese Society ofImmunology. 2016

6. Chyuan IT, Tsai HF, Hsu PN.Tumor necrosis factor-alpha blockage therapy impairs hepatitis Bviral clearance and enhances T-cell exhaustion in a mouse model[Poster]. The Congress of the Chinese Society of Immunology. 2015

7. Chyuan IT, Tsai HF, Hsu PN.Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)suppresses joint damage and protects against bone loss by inhibitingT cell activation and inflammation in experimental arthritis [Oral].The Congress of the Chinese Society of Immunology. 2014

8. Chyuan IT, Liao HJ, Hsu PN.Neutrophil infiltration, increased IL-1 production and SAPHOsyndrome-like phenotype in PSTPIP2 deficient mice [Poster]. The 15thInternational Congress of Immunology. Italy, 2013

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